Our Focus

Cancer Lipid Metabolism


Cancer Molecular Therapies


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Cancer Metabolism: Long History, Recent Breakthrough


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Fatty Acid Synthase, A Promising Cancer Drug Target


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Cancer Lipid Metabolism: Recent Breakthrough of FASN Inhibitors


• Investigator sponsored Phase 2 trial of TVB-2640 with Bevacizumab in Patients with First Relapse of High-Grade Astrocytoma 

       • 25 patients enrolled, both grade III and IV astrocytoma 

       • All patients received ASC40 (TVB-2640) (100mg/m2 PO QD) plus bevacizumab (10mg/kg IV D1,15) until treatment-related toxicity or progressive disease 

• The overall response rate (ORR) for ASC40 (TVB-2640) plus bevacizumab of 65% 

       • Complete response (CR) of 20% 

       • Partial response (PR) of 45% 

• Progression-free survival at six months (PFS6) for ASC40 (TVB-2640) plus bevacizumab was 47% 

       • Representing a statistically significant improvement in PFS6 over historical bevacizumab monotherapy (BELOB 16%, P=0.01) 

       • ASC40 (TVB-2640) in combination with bevacizumab was safe and well tolerated in such patient population 

• Presented at European Society for Medical Oncology 2020




Oral Checkpoint Inhibitors


PD-L1 Small Molecule Inhibitors: Challenges and Opportunities


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ASC63: Induce PD-L1 Dimerization and Sustained Internalization


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Publications


Title

Venue

Type

Date

Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade AstrocytomaClinical Cancer ResearchPaper
04/2023
In vivo Efficacy Evaluation of ASC61, an Oral PD-L1 Inhibitor, in Two Tumor Mouse ModelsThe 2022 Annual Meeting of the American Association for Cancer Research (AACR) Poster3/2022
Efficacy of ASC60, an Oral Fatty Acid Synthase Inhibitor,in Two Tumor Mouse ModelsThe 2022 Annual Meeting of the American Association for Cancer Research (AACR) Poster3/2022
First in human study of the first-in-class fatty acid synthase (FASN) inhibitor TVB-2640The 2017 American Association for Cancer Research (AACR) Annual MeetingPoster04/2017